BioCompLab

Principal Investigator

Postdocs

Research Assistant

Ph.D. Student

Master Student

Alumni

Hung-Lin Kan (甘鴻霖)

Post-Doctoral Associate (2022/09-present)

Institute of Biotechnology and Pharmaceutical Research,
National Health Research Institutes, Taiwan
Email: hlkan0422@nhri.edu.tw
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    Education:

  • 2017/09 - 2022/08, PhD, Doctoral Degree Program in Toxicology, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
  • 2015/09 - 2017/07, M.S., School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
  • 2010/09 - 2014/06, B.S., Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung, Taiwan

    Experience:

  • 2022/09 - present, Post-Doctoral Associate, Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, Taiwan

Scientific Publications

  1. H.L. Kan, Y.W. Chiu and C.W. Tung* (2025) Metaclassifiers and multitask learning for predicting toxicity endpoints with complex mechanism, Chapter in Machine Learning and Artificial Intelligence in Toxicology and Environmental Health (Zhoumeng Lin, Wei-Chun Chou, eds.), Academic Press, 153-171.
  2. H.L. Kan, S.S. Wang and C.W. Tung* (2025) ZFinfer: A Novel Chemical-Phenotype Inference System for Zebrafish for Filling Data Gaps in Environmental Pollutant Research, Ecotoxicology and Environmental Safety, 302, 118682.
  3. H.L. Kan, S.S. Wang, C.L. Liao, W.R. Tsai, C.C. Wang* and C.W. Tung* (2024) An Integrated Testing Strategy and Online Tool for Assessing Skin Sensitization of Agrochemical Formulations, Toxics, 12(12), 936.
  4. S.H. Hung, H.L. Kan, C.W. Tung, Y.C. Lin, T.T. Chen, C. Tian and W. C.W. Chang* (2024) Probing the hair detectability of prohibited substances in sports: an in vivo-in silico-clinical approach and analytical implications compared with plasma, urine, and faeces, Archives of Toxicology, 98, 779-790.
  5. H.L. Kan, C.W. Tung*, S.E. Chang and Y.C. Lin* (2022) In Silico Prediction of Parkinsonian Motor Deficits-related Neurotoxicants based on the Adverse Outcome Pathway Concept, Archives of Toxicology, 96(12), 3305-3314.
  6. W. C.W. Chang, H.Y. Wu, H.L. Kan, Y.C. Lin, P.J. Tsai, Y.C. Chen, Y.Y. Pan and P.C. Liao* (2021) Discovery of Spoilage Markers for Chicken Eggs Using Liquid Chromatography-High Resolution Mass Spectrometry-Based Untargeted and Targeted Foodomics, Journal of Agricultural and Food Chemistry, 69(14), 4331-4341.
  7. H.L. Kan, C.C. Wang, Y.C. Lin* and C.W. Tung* (2021) Computational Identification of Preservatives with Potential Neuronal Cytotoxicity, Regulatory Toxicology and Pharmacology, 119, 104815.
  8. C.L. Yang, H.C. Wu, T.L. Hwang, C.H. Lin, Y.H. Cheng, C.C. Wang, H.L. Kan, Y.H. Kuo, I.S. Chen, H.S. Chang* and Y.C. Lin* (2020) Anti-Inflammatory and Antibacterial Activity Constituents from the Stem of Cinnamomum validinerve, Molecules, 25(15), 3382.
  9. H.L. Kan, C.C. Wang, Y.H. Cheng, C.L. Yang, H.S. Chang, I.S. Chen and Y.C. Lin* (2020) Cinnamtannin B1 attenuates rosacea-like signs via inhibition of pro-inflammatory cytokine production and down-regulation of the MAPK pathway, 2020(8), e10548.

Conference Presentations

  1. M.C. Li, H.L. Kan, R.H. Lin, C.C. Wang and C.W. Tung* (2025) Predicting Molecular Initiating Events for Adverse Outcome Pathway-based Toxicity Evaluation Via Multitask Learning, 21th International Workshop on (Q)SAR in Environmental and Health Sciences (QSAR2025), Milan, Italy. Jun 3-6 (Poster).
  2. H.L. Kan, S.S. Wang and C.W. Tung* (2025) Zfinfer-Mixture: Zebrafish-Based Mixture Effect Inference System for Chemical Hazard Prioritization, 2025 NHRI Research Day, Miaoli City, Taiwan. Mar 25-26 (Poster).
  3. H.L. Kan, S.S. Wang and C.W. Tung* (2025) Inferring developmental mixture toxicity using a zebrafish-based toxicogenomic inference system, The 59th Congress of the European Societies of Toxicology (EuroTox 2025), Athens, Greece. Sep 14-17 (Poster).
  4. H.L. Kan* (2025) Inferring potential effects of PFASs via a novel chemical-phenotype inference system ZFinfer, ASCCT-ESTIV Award Winners Series Webinar, Online. Feb 20 (Oral). (Invited Speaker)
  5. H.K. Fan, S.S. Wang, H.L. Kan, Y.D. Wang, C.Y. Chang, C.C. Wang* and C.W. Tung* (2025) SkinSensDB 2.0: a comprehensive database of AOP assay data and transfer learning-based prediction model for skin sensitization, 21th International Workshop on (Q)SAR in Environmental and Health Sciences (QSAR2025), Milan, Italy. Jun 3-6 (Oral).
  6. H.K. Fan, H.L. Kan, Y.D. Wang, S.S. Wang, C.W. Tung* and C.C. Wang* (2025) SkinSensDB 2.0: An OECD TG-Oriented Database and Predictive Modeling Platform for Skin Sensitization, 2025 Chinese-Taipei Society of Laboratory Animal Sciences (CSLAS) Annual Conference. Taipei, Taiwan. Oct 2-3 (Oral). (Award: 2nd Place)
  7. C.C. Wang*, C.W. Tung, H.L. Kan and S.S. Wang (2024) SkinSensPred: Adverse Outcome Pathway-Based Multitask Learning Model for Human Skin Sensitizers, 24th European Symposium on Quantitative Structure-Activity Relationship (24th EuroQSAR), Barcelona, Spain. Sep 22-26 (Poster).
  8. C.W. Tung*, C.C. Wang, H.L. Kan, R.H. Lin, S.S. Wang and P. Lin (2024) Innovative Virtual Zebrafish Platform: Integrating QSAR and In Silico Toxicogenomics for Drug Discovery and Safety, 24th European Symposium on Quantitative Structure-Activity Relationship (24th EuroQSAR), Barcelona, Spain. Sep 22-26 (Poster).
  9. H.L. Kan, S.S. Wang and C.W. Tung* (2024) ZFinfer: An Innovative Chemical-Phenotype Inference System on Zebrafish to Fill Data Gaps in Environmental Pollutant Research, 2024 NHRI Research Day, Miaoli City, Taiwan. Mar 18-19 (Poster).
  10. H.L. Kan, S.S. Wang and C.W. Tung* (2024) Inferring potential effects of PFASs via a novel chemical-phenotype inference system ZFinfer, ASCCT 13th Annual Meeting, Research Triangle Park, NC, USA. Oct 28-30 (Poster).
  11. H.L. Kan, S.S. Wang, C.C. Wang and C.W. Tung* (2023) ChemDIS-ZF: a computational chemical–disease inference system for zebrafish, 12th World Congress on Alternatives and Animal Use in the Life Sciences (WC12), Niagara Falls, Canada. Aug 27-31 (Oral).
  12. H.L. Kan, S.S. Wang, C.C. Wang and C.W. Tung* (2023) Development and validation of a novel computational system for predicting zebrafish phenotypes associated with chemical exposure, The 10th International Congress of Asian Society of Toxicology (ASIATOX-X), Taipei, Taiwan. Jul 17-20 (Oral).
  13. H.L. Kan, C.W. Tung* and Y.C. Lin* (2022) Computational Identification of Parkinsonian Neurotoxins Using an Integrated Model Based on Adverse Outcome Pathway Concept, The 36th Joint Annual Conference of Biomedical Science, Taipei, Taiwan. Mar 25-27 (Oral).
  14. H.L. Kan, C.W. Tung, Y.C. Chen and Y.C. Lin* (2021) Mycobacterium Pup-ligase PafA as a Potential Target for Mycobacterial Infections, the 14th Asia Pacific Federation of Pharmacologists (APFP), Taipei, Taiwan. Nov 26-29 (Poster).
  15. H.L. Kan, C.W. Tung, Y.C. Chen and Y.C. Lin* (2021) In silico and in vitro screening of PafA inhibitors as antimycobacterial agents, 31st European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), Vienna, Austria. Jul 9-12 (Poster).
  16. H.L. Kan, S.S. Wang, C.C. Wang, Y.C. Lin* and C.W. Tung* (2020) Computational assessment of potential neurotoxicity associated with cosmetics preservatives, 2020 Taiwan Academic Network Conference (TANET2020), Taipei, Taiwan. Oct 28-30 (Poster).
  17. H.L. Kan, Y.C. Lin, C.C. Wang and C.W. Tung* (2019) Developing a QSAR model for predicting neurotoxic agents, The 15th International Congress of Toxicology (ICTXV), Honolulu, Hawaii. Jul 15–18 (Poster).
  18. H.L. Kan, Y.C. Lin, C.C. Wang and C.W. Tung* (2019) Computational Screening of Chemicals Toxic to Neuronal Cells, The 1st Winter Camp Congress of The Taiwan Society of Toxicology, Kenting, Taiwan. Jan 26–28 (Poster). (Honorable Mention)