BioCompLab

Principal Investigator

Postdocs

Research Assistant

Ph.D. Student

Master Student

Alumni

Wei-Cheng Huang (黃偉誠)

Postdoctoral Research Fellow (2021/11-current)

Institute of Biotechnology and Pharmaceutical Research,
National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County (35053), Taiwan
Email: drhuangwc@nhri.edu.tw

    Experience:

  • 2021/11 - now, Postdoctoral Research Scientist at Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taiwan
  • 2015/08 - 2020/12, Project Manager of Taiwan Protein Project and Postdoctoral Research Scientist at Institute of Biological Chemistry, Academia Sinica, Taiwan
  • 2015/08 - 2020/12, Visiting Research Scientist at RIKEN, Spring-8 synchrotron, Japan
  • 2014/07 - 2015/08, Postdoctoral Research Associate at Department of Biochemistry, National Chung-Hsing University, Taiwan
  • 2008/07 - 2012/04, Postdoctoral Research Associate at Department of Biochemistry, University of Leicester, UK

    Education:

  • 2004/07 - 2008/07, Ph.D., Department of Biochemistry, University of Leicester, United Kingdom
  • 1998/09 - 2000/06, M.S., Department of Biochemistry, College of Life Science at National Chung-Hsing University
  • 1994/09 - 1998/06, B.S., Department of Botany, College of Life Science at National Chung-Hsing University

Scientific Publications

  1. W.C. Huang, W.T. Lin, M.S. Hung, J.C. Lee and C.W. Tung (2024) Decrypting orphan GPCR drug discovery via multitask learning, Journal of Cheminformatics, 16(1), 10.
  2. M. M.R., P.H. Wang, E. Nango, Y. Hosokawa, M. Saft, A. Furrer, C.H. Yang, E. Putra Gusti Ngurah Putu, W.J. Wu, H.J. Emmerich, N. Caramello, S. F.B., C. Yang, S. Engilberge, M. Wranik, H. Louise Glover, T. Weinert, H.Y. Wu, C.C. Lee, W.C. Huang, K.F. Huang, Y.K. Chang, J.H. Liao, J.H. Weng, W. Gad, C.W. Chang, A. H. Pang, K.C. Yang, W.T. Lin, Y.C. Chang, D. Gashi, E. Beale, D. Ozerov, K. Nass, G. Knopp, P. J. M. Johnson, C. Cirelli, C. Milne, C. Bacellar, M. Sugahara, S. Owada, Y. Joti, A. Yamashita, R. Tanaka, T. Tanaka, F. Luo, K. Tono, W. Zarzycka, P. Müller, M. Alkheder Alahmad, F. Bezold, V. Fuchs, P. Gnau, S. Kiontke, L. Korf, V. Reithofer, C. Joshua Rosner, E. Marie Seiler, M. Watad, L. Werel, R. Spadaccini, J. Yamamoto, S. Iwata, D. Zhong, J. Standfuss, A. Royant, Y. Bessho, L.O. Essen and M.D. Tsai (2023) Visualizing the DNA repair process by a photolyase at atomic resolution, Science, 382(6674), eadd7795.
  3. P.W. Chang, J.Y. Wang, W.P. Wang, W.C. Huang, M.H. Wu, J.S. Song, L.Y. Chen, C.W. Tung, Y.H. Chi and S.H. Ueng (2023) Analysis of structure–activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors, Bioorganic & Medicinal Chemistry, 95, 117502.
  4. W.C. Hsiao, G.H. Niu, C.F. Lo, J.Y. Wang, Y.H. Chi, W.C. Huang, C.W. Tung, P.J. Sung, L. Kelvin Tsou and M. M. Zhang (2023) Marine diterpenoid targets STING palmitoylation in mammalian cells, Communications Chemistry, 6(1), 153.
  5. M. M.R., C.H. Yang, E. Nango, W.C. Huang, E. Putra Gusti Ngurah Putu, W.J. Wu, P.H. Wang, S. F.B., M. Saft, H.J. Emmerich, H.Y. Wu, C.C. Lee, K.F. Huang, Y.K. Chang, J.H. Liao, J.H. Weng, W. Gad, C.W. Chang, A. H. Pang, M. Sugahara, S. Owada, Y. Hosokawa, Y. Joti, A. Yamashita, R. Tanaka, T. Tanaka, F. Luo, K. Tono, K.C. Hsu, S. Kiontke, I. Schapiro, R. Spadaccini, A. Royant, J. Yamamoto, S. Iwata, L.O. Essen, Y. Bessho and M.D. Tsai (2022) Serial crystallography captures dynamic control of sequential electron and proton transfer events in a flavoenzyme, Nature Chemistry.
  6. M. M.R., J. Yamamoto, W.C. Huang, M.D. Tsai, L.O. Essen and Y. Bessho (2018) Twist and turn: a revised structural view on the unpaired bubble of class II CPD photolyase in complex with damaged DNA, IUCrJ, 5(5), 608-618.
  7. E. S.W. Chen, J.H. Weng, Y.H. Chen, S.C. Wang, X.X. Liu, W.C. Huang, T. Matsui, Y. Kawano, J.H. Liao, L.H. Lim, Y. Bessho, K.F. Huang, W.J. Wu and M.D. Tsai (2017) Phospho-Priming Confers Functionally Relevant Specificities for Rad53 Kinase Autophosphorylation, Biochemistry, 56(38), 5112-5124.
  8. T.L. Ho, H.C. Lee, Y.L. Chou, Y.H. Tseng, W.C. Huang, C.H. Wung, N.S. Lin, Y.H. Hsu and B.Y. Chang (2017) The cysteine residues at the C-terminal tail of Bamboo mosaic virus triple gene block protein 2 are critical for efficient plasmodesmata localization of protein 1 in the same block, Virology, 501, 47-53.
  9. H.H. Kuo, W.C. Huang, T.F. Lin, H.Y. Yeh, K.M. Liou and B.Y. Chang (2015) The core-independent promoter-specific binding of \textitBacillus subtilis σ $^\textrmB$, FEBS Journal, 282(7), 1307-1318.
  10. W.C. Huang, J. Ellis, P. C.E. Moody, E. L. Raven and G. C.K. Roberts (2013) Redox-Linked Domain Movements in the Catalytic Cycle of Cytochrome P450 Reductase, Structure, 21(9), 1581-1589.
  11. M. Jenner, J. Ellis, W.C. Huang, E. Lloyd Raven, G. C. K. Roberts and N. J. Oldham (2011) Detection of a Protein Conformational Equilibrium by Electrospray Ionisation-Ion Mobility-Mass Spectrometry, Angewandte Chemie International Edition, 50(36), 8291-8294.
  12. W.C. Huang, P. M. Cullis, E. Lloyd Raven and G. C. K. Roberts (2011) Control of the stereo-selectivity of styrene epoxidation by cytochrome P450 BM3 using structure-based mutagenesis, Metallomics, 3(4), 410.
  13. J. Ellis, A. Gutierrez, I. L. Barsukov, W.C. Huang, J.Günter Grossmann and G. C.K. Roberts (2009) Domain Motion in Cytochrome P450 Reductase, Journal of Biological Chemistry, 284(52), 36628-36637.
  14. W.C. Huang, A. C.G. Westlake, J.D. Maréchal, M. Gordon Joyce, P. C.E. Moody and G. C.K. Roberts (2007) Filling a Hole in Cytochrome P450 BM3 Improves Substrate Binding and Catalytic Efficiency, Journal of Molecular Biology, 373(3), 633-651.
  15. H.H. Hsu, W.C. Huang, J.P. Chen, L.Y. Huang, C.F. Wu and B.Y. Chang (2004) Properties of Bacillus subtilis ␴A Factors with Region 1.1 and the Conserved Arg-103 at the N Terminus of Region 1.2 Deleted, J. BACTERIOL., 186, 10.
  16. Y.D. Wen, C.T. Liao, K.M. Liou, W.H. Wang, W.C. Huang and B.Y. Chang (2000) Structural and functional properties of aBacillus subtilis temperature-sensitive ?A factor, Proteins: Structure, Function, and Genetics, 40(4), 613-622.